Endocrine Abstracts

The kidney plays a vital role in the Ca2+ homeostasis by determining the excretion of Ca2+ from the body. The fine-tuning of Ca2+ excretion takes place in the distal convoluted and connecting tubule, where Ca2+ is actively reabsorbed via the transcellular pathway. A major breakthrough in completing the molecular details of this pathway was the identification of the epithelial Ca2+ channel TRPV5. Functional analysis ...

Transient receptor potential cation channel, subfamily Vanilloid, member 5 (TRPV5) is a member of the TRP superfamily. TRPV5, which functions as a tetramer, is localized to apical membranes of distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, and is involved in vitamin D-regulated calcium reabsorption. Mice with a targeted deletion of Trpv5 (Trpv5−/−) develop severe hypercalciuria, compensatory hyperabsorption of dietary ...